Ingredient Spotlight

Bupleurum / Chai Hu

Traditionally supports: Energy balance, Menstrual comfort, Head tension, and Emotional steadiness

How It's Used

In Chinese herbal traditions, Bupleurum is cherished for its ability to clear heat, support the flow of energy (yang Qi), and ease tension. It is often used to promote liver balance and support emotional harmony.

In Western herbal practices, Bupleurum is valued for its natural antioxidant and soothing properties. It is associated with encouraging respiratory comfort and promoting ease in both body and mind.

Fun Fact: Bupleurum has been a staple in herbal formulations for centuries, valued for its versatility and ability to bring balance to holistic practices.

"Bupleurum plants are usually collected in spring and winter for medicinal purposes. The stems, leaves, and dirt are removed, and the roots are then dried in the sun."

- Lulu Ge, Founder

What the research says.

Proven by 13,854 studies (and counting), doctors of all backgrounds can finally agree on the healing properties of this powerful herb.

Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology

Chai Hu has major bioactive compounds such as: triterpenoid saponins, flavonoids, and essential oils that produce anti-inflammatory, anticancer, antipyretic, antimicrobial, antiviral, hepatoprotective, neuroprotective, and immunomodulatory effects.

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Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress

Chai Hu can restore neuroendocrine, neuroinflammation, and neurotrophic systems in the hippocampus.

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Current Issue Forthcoming Issue Special Issues Most Read Most Cited (Dimensions) Most Cited (CrossRef) Social Media Archive Information Online Submission Information for Authors Language Editing Information for Reviewers Editorial Policies Editorial Board Join Editorial Board Aims and Scope Abstracting and Indexing Bibliographic Information Information for Librarians Information for Advertisers Reprints and permissions Contact the Editor General Information About Spandidos Conferences Job Opportunities Contact Terms and Conditions Saikosaponin A mediates the inflammatory response by inhibiting the MAPK and NF-κB pathways in LPS-stimulated RAW 264.7 cells

Saikosaponin A is a major active component of Chai Hu and produces an anti-inflammatory effect by regulating inflammatory mediators and suppressing the MAPK and NF-kB signaling pathways in LPS-stimulated cells.

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Saikosaponin D relieves unpredictable chronic mild stress

Chai Hu has Saikosaponin D, which relieves stress and reduces depression-like behavior by enhancing the HPA (hypothalamic–pituitary–adrenal) axis function and consolidates hippocampal glucocorticoid receptors.

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